Cefuroxime is used to treat bacterial infections of the tonsils, throat, sinus, ears, respiratory tract, urinary tract, skin infections, and soft tissue.
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Cefotil 250mg Tablet is used to treat various bacterial infections, including urinary tract infections (UTI), bronchitis, pneumonia, pyelonephritis, uncomplicated gonorrhea, and Lyme disease in adults and children above 12 years of age.
It is a broad-spectrum antibiotic that kills bacteria by binding to their outer layer and blocking the activity of an enzyme involved in the production of peptidoglycan, an essential component of the bacterial cell wall. This prevents bacterial growth and leads to the death of the bacteria.
It is important to take Cefotil 250mg Tablet only if prescribed by your doctor. It is available in different forms such as oral tablets, dispersible tablets, and oral suspension.
Most bacterial infections are treated within one week, but the duration of treatment may vary. It is advisable to complete the full course of medication prescribed by your doctor for the specific infection.
Common side effects of Cefotil 250mg Tablet may include headache, dizziness, stomach upset, fungal skin infections (such as candida overgrowth), unpleasant taste in the mouth, diaper rashes, and increased white blood cell count (eosinophilia). These side effects are usually mild and temporary.
Overdosing on Cefotil 250mg Tablet can lead to cerebral irritation and seizures. It is important to take the medication as prescribed and not exceed the recommended dosage.
There is limited clinical evidence regarding the effects of Cefotil 250mg Tablet on pregnant or breastfeeding individuals. It is advisable to use caution during pregnancy and for nursing mothers due to the excretion of the medication in breast milk.
Cefotil 250mg Tablet may cause dizziness, so it is important to be cautious while driving or operating machinery.
Individuals who are allergic or hypersensitive to Cefotil 250mg Tablet, penicillin, or other beta-lactam antibiotics should avoid taking this medication.
The use of Cefotil 250mg Tablet may disrupt the natural balance of gut flora, leading to diarrhea and abdominal cramps. Your doctor may prescribe prebiotics or probiotics to help restore the gut flora.
Cefotil 250mg Tablet does not have significant interactions with alcoholic beverages.
Individuals with liver or kidney problems should takeCefotil 250mg Tablet with caution
It is not known how the medication might react upon interaction with alcohol and so it is advised that you seek the permission from your doctor before deciding to consume it.
Pregnant women should not use this medication. Consult your doctor before using this medication. Potential benefits and risks involved should be given due consideration before administration.
Women who are breastfeeding should avoid taking this medication as it can pass into the milk and affect the joints of the baby.
You may feel dizzy while on treatment with the Cefotil 250mg Tablet. Caution is needed while driving or operating machines.
Only limited information is available regarding its use in patients with kidney disease. Kindly consult your doctor before Cefotil 250mg Tablet
Only limited information is available regarding its use in patient with liver disease. Kindly consult your doctor before taking this medication.
Used to treat:
The drug belongs to the second generation cephalosporins. It works as a bactericidal by inhibiting the bacterial cell wall synthesis by binding to the penicillin binding proteins which would inhibit the growth and multiplication of bacteria.
It is indicated for the treatment of infections caused by sensitive bacteria. Pharingitis / Tonsilite caused by Pyogenes Streptococcus.
Cefuroxime is indeed a bactericidal antibiotic belonging to the second-generation cephalosporin class. It has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, including strains that produce beta-lactamase enzymes, which are capable of breaking down beta-lactam antibiotics.
Cefuroxime works by interfering with the transpeptidation process, which is involved in the synthesis of bacterial cell walls. By inhibiting this process, cefuroxime prevents bacteria from forming a functional cell wall, ultimately leading to their death.
To enhance the effectiveness of cefuroxime against beta-lactamase-producing bacteria, it is often combined with clavulanic acid, which is a naturally derived beta-lactamase inhibitor. Clavulanic acid has a structure similar to beta-lactam antibiotics and has the ability to irreversibly bind to beta-lactamase enzymes, rendering them inactive. This mechanism of action allows cefuroxime to remain effective against bacteria that would otherwise produce beta-lactamase enzymes to break down the antibiotic.
The combination of cefuroxime with clavulanic acid is commonly used to treat bacterial infections, particularly those caused by multidrug-resistant bacteria or those involving beta-lactamase-producing strains. This combination therapy helps overcome the resistance mechanisms employed by certain bacteria, making it an effective treatment option for a range of infections.
Adult Dose:
Child Dose:
Children: Oral - 20-30 mg/kg/day divided into two doses every 12 hours. For bone and joint infections, up to 100 mg/kg/day. Intravenous or Intramuscular - 100-150 mg/kg/day divided into three doses every 8 hours.
Renal Dose:
In patients with renal impairment, the dose adjustment is as follows:
Please note that these dosing recommendations are a general guideline, and the actual dosage prescribed by your physician may vary based on individual factors such as age, body weight, and the severity of the infection. Always follow your doctor's instructions and take Cefotil 250mg Tablet as advised.
Drug-Drug Interactions:
Drug-Food Interactions:
Drug-Disease Interactions:
Regarding the interaction with alcohol, there is no specific information available. It is recommended to consult your doctor regarding the consumption of alcohol while taking Cefotil 250mg Tablet.
Always inform your healthcare provider about all the medications (prescription, over-the-counter, herbal) and medical conditions you have before starting any new medication to ensure safe and effective treatment.
Cefuroxime is not recommended for people who have a Cephalosporin allergy.
Antibiotics should be avoided if at all possible throughout the first trimester. Cefuroxime-Clavulanic Acid, on the other hand, can be safely used to treat urinary and other infections later in pregnancy. Cefuroxime-Clavulanic Acid is excreted in modest amounts in breast milk. However, the possibility of the newborn being sensitized should be considered.
Allergic reactions: Individuals with known allergies to penicillin or other beta-lactam antibiotics may have an increased risk of developing an allergic reaction to Cefotil 250mg Tablet. It is important to inform your doctor about any known allergies before starting the medication.
Fungal skin infection: Prolonged use of Cefotil 250mg Tablet or use in combination with other antibiotics may lead to an overgrowth of fungi, specifically Candida, causing a fungal skin infection. If you develop symptoms such as skin rash, itching, or discharge, it is important to inform your doctor.
Overgrowth of other pathogens: Prolonged use of Cefotil 250mg Tablet may lead to the overgrowth of certain bacteria, such as enterococci and Clostridium difficile. If you experience persistent diarrhea or worsening symptoms, it is important to discontinue the medication and consult your doctor.
Colitis: There have been reports of colitis (inflammatory bowel disease) associated with the use of Cefotil 250mg Tablet. If you develop severe or persistent diarrhea, it is important to seek medical attention and consider the proper diagnosis of the condition.
Jarisch-Herxheimer reaction: In the treatment of Lyme disease, the use of Cefotil 250mg Tablet may cause a reaction known as the Jarisch-Herxheimer reaction. This reaction occurs due to the release of toxins when bacteria are killed by the antibiotic. Symptoms may include fever, chills, headache, muscle aches, and increased skin rash. It is important to be aware of this possibility and seek medical advice if such symptoms occur.
Impaired cognitive and motor function: Cefotil 250mg Tablet may cause dizziness and affect cognitive and motor functions. Patients should be cautious when driving or operating machinery and should avoid tasks that require judgment or concentration until they know how the medication affects them.
Severe renal impairment, pregnancy, and lactation: Cefotil 250mg Tablet should be used with caution in individuals with severe renal impairment. It should be used during pregnancy or lactation only if the potential benefits outweigh the risks and under the guidance of a healthcare professional.
Store in a cool, dry place (below 30° C), away from light & moisture. Keep out of the reach of children.
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